Anesthetic Effects on γ-Aminobutyric Acid A Receptors
نویسندگان
چکیده
منابع مشابه
Anesthetic effects on γ-aminobutyric acid A receptors: not just on your nerves.
1013 May 2013 I N this current issue of Anesthesiology, Xiang et al.1 describe the effects of volatile anesthetic activation of type A γ-amino butyric acid (GABAA) receptors expressed on airway epithelial cells. It has long been appreciated that a key mechanism in the action of general anesthetics in the brain involves the anesthetics’ allosteric potentiation of GABA on GABAA receptors, thereby...
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Since the cloning of the first γ-aminobutyric acid (GABA) transporter (GAT1; SLC6A1) from rat brain in 1990, more than 50 published studies have provided structure-function information on investigator-designed rat and mouse GAT1 mutants. To date, more than 200 of 599 GAT1 residues have been subjected to mutagenesis experiments by substitution with different amino acids, and the resulting transp...
متن کاملEfficient Modulation of γ-Aminobutyric Acid Type A Receptors by Piperine Derivatives
Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates γ-aminobutyric acid type A receptors (GABAAR). We have synthesized a library of 76 piperine analogues and analyzed their effects on GABAAR by means of a two-microelectrode voltage-clamp technique. GABAAR were expressed in Xenopus laevis oocytes. Structure-activity relationships (SARs) were ...
متن کاملIsoflurane regulates atypical type-A γ-aminobutyric acid receptors in alveolar type II epithelial cells.
BACKGROUND Volatile anesthetics act primarily through upregulating the activity of γ-aminobutyric acid type A (GABAA) receptors. They also exhibit antiinflammatory actions in the lung. Rodent alveolar type II (ATII) epithelial cells express GABAA receptors and the inflammatory factor cyclooxygenase-2 (COX-2). The goal of this study was to determine whether human ATII cells also express GABAA re...
متن کاملA Review on Gamma-aminobutyric Acid (gaba) and Its Receptors
The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), activates a variety of receptors in all areas of the central nervous system (CNS). GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre and postsynaptic neuronal processes. There are three classes of GABA receptors. GABAA and GABAC receptors are ionotropic in n...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2013
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e31828e1865